Sex differences in pain perception and interpretation

This study tries to explain the importance of sex differences in the perception of pain and its treatment. The study examines sex differences not only between men and women, but more generally – between males and females. The study deals with both experimental and clinical findings. Generally speaking, women have lower pain thresholds and they also differ in their response to analgesic therapy (e.g. opioids). We focused our attention on a description of painful symptoms and syndromes, their pathophysiology and treatment. This study aims to contribute to a better understanding of the pathophysiology of chronic pain, particularly since it affects about 30% of the population. Proper treatment should be based on the pathophysiology and pharmacology of pain phenomena. The study also presents therapeutic experiences and possible clinical applications. Our article intends to promote good clinical practice based on evidence-based medicine.